I grew up in France and attended the Institut National des Sciences Appliquées, an engineering school where I graduated with a Master in Biochemistry. I attended graduate school at the University J. Fourier in Grenoble, France with a focus on Molecular Biology with Dr. Michel Vivaudou. I then came to National Jewish Health in Denver, Colorado for my Post-doc and never looked back. My main scientific interests and contributions are in the area of respiratory infection and innate immune responses in the context of lung diseases, including, but not limited to, asthma and chronic obstructive pulmonary disease (COPD). My current research emerged from a rather original study where, using Caenorhabditis elegans, we identified the lipid binding protein 7 (lbp-7) to be down regulated after cigarette smoke exposure and to play a role in innate immunity. The human orthologue of lbp-7 is fatty acid binding protein 5 (FABP5), which is down regulated in COPD patients. Since then, I have used several in vitro and in vivo approaches involving cigarette smoke exposure in the context of bacterial and viral infections to understand the role of FABP5 in COPD exacerbations. Indeed, studies show that cigarette smoke compromises the immune system and that inflammation is critical for the host defense against bacterial infection and the recovery process. However, ineffective clearance of microorganisms elicits prolonged inflammation, which may contribute to the pathogenesis of smoking-related diseases such as COPD. I built my current research grant on the hypothesis that FABP5 may be implicated in the vicious cycle of non-resolution of inflammation in COPD exacerbations and was recruited as an Assistant Professor in the Department of Immunology and Genomic Medicine at National Jewish Health. My lab has developed techniques to interrogate Fabp5 gene regulation, and to complement mouse models of COPD exacerbations, we are using patients’ blood samples to link FABP5 deficiency with decreased immune functions in COPD patients with frequent exacerbations.