My career has focused on the mechanisms controlling early vertebrate development. Specifically, my lab studies the characterization of the molecular networks that regulate cardiac formation and function and how perturbations of these networks lead to heart disease. This work is highly integrative and encompasses molecular/epigenetic, genetic, cellular, and biochemical/proteomic based approaches. The work has been continuously funded (both from NIH and from private agencies) since I became an independent investigator. During my career, I have mentored pre-doctoral fellows who, without exception, have gone on to high profile post-doctoral or academic positions. In addition, I have served as Associate Director of the Cell & Molecular Biology Training Program and am presently Co-Director of the Training Program in Cellular Systems and Integrative Physiology. I also presently serve as Director of Proteomics, McAllister Heart Institute at UNC.