Comparative medicine is the study of disease in humans and animals, looking at similarities and differences between the two. Dr Michael Kent is a radiation oncologist with the UC Davis School of Veterinary Medicine. Dr. Kent collaborates with Dr. Arta Monjazeb, a radiation oncologist at the UC Davis Comprehensive Cancer Center, to examine the use of a novel triple therapy to treat advanced cancer in dogs. Tumors that have already spread to other parts of the body are the most challenging to treat. Conventional radiation and immune therapy were combined in a clinical trial in dogs. This is a great example of how physicians and veterinarians can work together to tackle a disease that affects both species. Dr Kent, who also serves as director of the Center for Companion Animal Health said it is important to refine and improve the technique so it can be used for both dogs and humans.

Investigators

• Michael S. Kent, DVM
• Arta Monjazeb, MD, Ph.D

Three key benefits of the findings

• The results of the clinical trial showed that this approach was effective and extended the lives of some dogs while maintaining quality of life.
• This triple combination of therapies had anti-tumor effects and decreased the spread of cancer in dogs.
• The limited toxicity of this strategy are attractive for translation into human clinical trials.