This project addresses two critical needs in the canine epilepsy field, identification of effective treatments and development of validated outcome measures. Specifically, the proposed prospective, placebo-controlled, pilot clinical trial will identify associations between diet and seizures in canines and test FitBark actigraphy as a potential outcome measure to correlate seizure activity with diet.
Interferon lambda (IFN-λ) is a cytokine that exerts antiviral effects at anatomic barriers but its effects in the skin have not been extensively investigated. We will use transgenic mouse models to study the effects of IFN-λ in viral skin infections as well as in the inflammatory condition atopic dermatitis (eczema).
Enhancing clinical decision-making through the application of artificial intelligence and machine learning. Dr. Reagan’s lab focuses on rapid and non-invasive methods to diagnose infection, including developing point-of-care diagnostics for systemic mycosis, novel molecular diagnostics utilizing CRISPR technology, and machine learning tools to detect patterns in patient biomarker data.
This team is focused on the interaction between cutaneous immune system and microbes. The main research of this group involves the interaction between Staphylococci and keratinocytes in canine and human skin disorders.
The Canine Aging and Cognitive Dysfunction research program at Colorado State University, consisting of a multidisciplinary team, uses the dog as an animal disease model to
study aging and cognitive dysfunction. The primary goals of the research program are to develop diagnostic approaches for early identification of cognitive dysfunction, to understand the
mechanism and associated risk factors involved in brain aging and cognitive decline, and to engage in therapeutic translational clinical trials utilizing the dog as a large animal surrogate for
Traditional chemotherapy such as doxorubicin causes cardiac injury, limiting its use in cancer treatment. Dysregulation of the autophagic flux in cardiomyocytes secondary to doxorubicin treatment is known to occur. We aim to understand how this dysregulation contributes to cardiomyocyte cell death, and if the autophagic flux can be manipulated to prevent loss of cardiomyocytes with cancer therapy.
Current projects include genetic investigations of spinal and other musculoskeletal conditions, neurologic diseases such as polyneuropathy, ophthalmic diseases such as pigmentary uveitis in Golden Retrievers, and others (e.g dwarfism, vaccine response).
Gut bacteria (microbiota) may contribute to the variable individual responses to IBD drugs. Accurately predicting detrimental or beneficial drug responses for individuals will guide precise, personalized strategies for optimal therapeutic approaches, thus improving quality of life for all IBD patients.
Our research program focuses on the role of nutrition in the development, progression, and treatment of cardiac diseases, including degenerative mitral valve disease, hypertrophic cardiomyopathy, and dilated cardiomyopathy.
The objectives of this research are to develop clinical methods to characterize ultrastructural features of bone and cartilage that are associated with the progressive development of joint diseases such as subchondral insufficiency, osteonecrosis, progressive articular cartilage damage, and osteoarthritis.
The broad objectives of this research are to investigate recombinant lubricin and mucin therapeutics for the treatment of musculoskeletal diseases, including osteoarthritis, orthopedic infection and wound healing.
Main areas include investigation of the anti-inflammatory and anti-microbial properties of Stem Cell derived Extracellular Vesicles with the ultimate goal being to treat neuroinflammation. The model of choice for the proposed experiments will be feline Sandhoff disease, a single-gene disorder with inflammatory features typical of all neurodegenerative diseases. The model has been extensively characterized and used for the assessment of gene therapy in a unique research colony that is maintained at Auburn University.
Salmonella is a foodborne illness that infects millions of people worldwide, causing illness ranging from mild
gastroenteritis to septicimia and enteric fever. The goal of this research is to leverage recent technical advances we have made to: (1) gain a better understanding of a metabolic pathway that is
essential to how pathogens communicate with and manipulate their hosts and (2) to identify and profile receptors within this system that can potentially be targeted to disrupt the establishment and
maintenance of infection and prevent the emergenc of drug resistance.
Our collaborative team of basic and clinical scientists from the College of Medicine and Veterinary Medicine at the University of Florida (UF) applies inter-related translational science to develop a wide variety of approaches, including animal models directed at understanding the mechanisms through which the kidneys maintain the correct acid-base balance in the body. We are particularly interested in acid-base balance during chronic kidney disease (CKD), in which abnormalities in acid-balance result in increased progression and mortality of CKD.
This project will investigate the role of increased intestinal permeability (i.e., “leaky gut”) as a contributor to development and worsening of osteoarthritis at multiple joint sites in humans and a naturallyoccurring
osteoarthritis model in pet dogs.
The fellowship will focus on invasive urinary bladder cancer and will include veterinary clinical study at Purdue University, exposure to human bladder cancer clinics and research at Johns Hopkins University, and applied laboratory research at both institutions.
The primary goal of the Vector-Borne Disease Epidemiology, Ecology, and Response (VEER) Hub is to develop and implement evidence-based, surveillance, response, and control strategies to protect people, animals, and livelihoods from the threat posed by vector-borne diseases.
Colorado State University and the University of Colorado Anschutz
The trainee will have the unique opportunity to work closely with experts in bioinformatics, comparative genomics, medical informatics, and translational informatics, data semantics, and heterogeneous data integration. Colorado Clinical Translational Science Institute training opportunities, national and regional conferences, and involvement in a multi-year COHA initiative on ‘One Health Datasets’ will afford unique opportunities and excellent potential for career development in a new and growing field in veterinary and comparative medicine.
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